Ostarine is the Selective Androgen Receptor Modulators (SARMs) that is being developed for the prevention and treatment of muscle wasting. It is currently undergoing clinical trials and may eventually be the medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testosterone Replacement Therapy.
As a research chemical, Ostarine Selective Androgen Receptor Modulators belongs to a class of chemicals known as SARMs or Selective Androgen Receptor Modulators. SARMs create selective anabolic activity at certain androgen receptors and not others, hence their name. Compared to testosterone and other anabolic steroids and pro hormones, the advantage of Selective Androgen Receptor Modulators such as (Ostarine) MK-2688 is that they do not have androgenic activity in non-skeletal-muscle tissues.
Ostarine Selective Androgen Receptor Modulator is effective in not only maintaining lean body mass (LBM) but actually increasing it.
How does it work?
Selective Androgen Receptor Modulator (SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
Selective Androgen Receptor Modulator activation Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis, hence builds muscle in the form of lean body mass.
So in essence, Selective Androgen Receptor Modulator such as Osta causes muscle growth in the same manner as anabolic steroids, however unlike testosterone and other anabolic steroids and prohormones, Selective Androgen Receptor Modulator (as non steroidal agents) don’t produce the growth effect on prostate and other secondary sexual organs.
Osta in particular exerts its anabolic steroid like effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for Bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations. So enhanced lean body mass.
Now the gains in absolute weight will almost exclusively be lean mass muscle gains and muscle strength.
Due to the lack of shutdown in comparison to steroids/prohormones, a PCT period is not needed and almost all the mass that is gained on Ostarine is kept once the cycle is finished even though it is a potent anabolic agent.
Doses of 25mg for 4-6 weeks are the most common protocol for such goals. Over this 4-6 week period will typically produce 6lbs or 3kg of lean, keepable gains.
However the abundant adverse effects of steroids/prohormones will not be present, quite the opposite producing many beneficial effects.
Users have as high as 36mg [only recommended for those who weigh in at 210lbs (95kg)+] for periods as long as 8 weeks.
However the potential for suppression from such doses is higher and users would have to look into a PCT protocol after undergoing such a cycle.
Losing Body fat (cutting) Osta Selective Androgen Receptor Modulator would primarily fit into a cutting protocol for the maintenance of muscle mass whilst reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass.
The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue. As Osta has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss. Osta has also shown noticeable nutrient partitioning effects among users, another reason why it can be of great help when cutting.
A 10-15mg dosing protocol for 4-6 weeks is good for cutting with Selective Androgen Receptor Modulator Ostarine without undergoing any side effects or suppression.
Recomping (muscle growth and losing body fat at the same time)
In our opinion, along with lean gains in muscle mass, Recomping is where Ostarine Selective Androgen Receptor Modulator really shines.
The recomping effect of losing fat and gaining muscle bulk at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult.
Where Ostarine shines for recomping is in its nutrient partitioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that Osta consumed at maintenance calories produces weight loss, whilst still getting increases in strength and muscle mass!
One of the most important factors of recomping is TIME.
Although Ostarine is taken orally, as it is not methylated it is not as liver toxic as other oral steroids/prohormones so doesnt have the negative side effects.
Therefore it can be run for longer than the standard 4 week period with the aforementioned compounds.
The dosing protocol of 10-25mg for 4-8 weeks will give excellent recomp effects.
Diet must also be optimized to where calories are just above maintenance with at least 30% coming from lean sources of protein to get the best recomp effect.
Timing of Doses
As Osta has a half life of around 24 hours, each of these dosages only has to be taken orally once a day, therefore its also offers an extremely convenient supplementation intake.
Osta and estrogen concern
SARMs cannot be aromatised, conferring all their effects to Selective Androgen Receptor Modulator binding and not to metabolic conversion to active androgens/estrogens.
However blood work from users has shown a slight elevation in serum estradiol levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses.
This elevation is extremely small and is no case for concern. If however you are absolutely concerned about slight increases in Estrogen, you can always opt for low doses of over the counter PCT such as THOR
Evaluation of Ostarine Summary
Anabolic Activity even at doses as low as 3mg
Great for strength
Great for lean mass gains / muscle growth
Great for body recomposition
Great for endurance (aerobic or anaerobic)
Joint healing abilities