All about Nvrenuf DROL LGD-4033

Posted by Mark Hamilton on

What is Ligandrol LGD 4033 (DROL)?

Ligandrol LGD-4033 selective androgen receptor modulator (SARMS), and a novel non-steroidal oral SARM that binds to Androgen Receptors with high affinity and selectivity. It’s in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss.

What Effects can you expect from SARM LGD-4033

Effects similar to anabolic steroids with size and strength Minimal Adverse Effects Excellent for recomping Healing properties Prevents muscle wasting Works well as a stand alone or stacked with other selective androgen receptor modulator  Great results in every aspect for different types of goals Half life of 24-36 hours with oral administration

Bulking and Athletic performance


Ligandrol LGD-4033 Selective Androgen Receptor Modulator is the strongest Nutritional Supplement of all the SARMs in terms of the size you can gain & is very popular for putting on bulk muscle and increasing muscle strength.


Ligandrol LGD-4033 Selective Androgen Receptor Modulator studies have claimed increases in bone density, skeletal muscle mass, athletic performance, muscle strength and sex drive, without damaging prostate or liver tissue.


It’s in a group of Androgen Receptor (AR) ligands that are tissue selective, created to cure muscle wasting linked with acute and chronic diseases, age-related muscle loss and cancer. Ligandrol LGD-4033 Selective Androgen Receptor Modulator is anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.


Ligandrol LGD-4033 Selective Androgen Receptor Modulator is a nutritional supplement that works by tying androgen receptors selectively. It shows anabolic activity in the bones and muscles instead of harmfully affecting the prostate and sebaceous glands.


Clinical runs also showed that Ligandrol LGD-4033 Selective Androgen Receptor Modulator has the ability to set off the following benefits when taken consistently: an increase in strength levels, lean muscle mass, a drop in body fat, has healing properties and does not cause the undesirable side effects caused by body building supplements.

Ligandrol LGD-4033 has shown huge anabolic activity, with the most ability of any SARM to put on lean muscle mass that could be considered a bulk. This will, of course, be dependent upon the diet used. Users that have experienced more than 10lb. increases, and have had a significant increase in calorie intake. The possibility of this type of lean body mass is present with SARM Ligandrol LGD-4033 use.

Ligandrol Benefits

Skeletal Muscle Mass

In phase I clinical trials, LGD 4033 has produced notable increases in lean muscle mass . One group of healthy young men were given 1.0-Mg Dose for 3 weeks and after dose testing gained 1.21kg (2.67lbs). Considering the short cycle, small dosage and there being no training stimulus to maximize muscle gains — these are very positive results.

Muscular Strength and Muscle Gains

In the above-cited study, the men also recorded increased leg press strength and power on the stair-climber, before and after the 3-week cycle. This is despite not regularly performing these specific exercises throughout the trial.

Weightlifters often report making exceptional strength gains on LGD 4033, even when in a calorie deficit.

Adding 30+lbs to a squat or bench press 1RM is relatively common after a cycle of LGD 4033, with its effects on strength being superior to its ability to add lean muscle.

LGD 4033 does not produce any notable fat loss, unlike Ostarine or Cardarine; making it more optimal for bulking than cutting.


Daily doses for Ligandrol LGD-4033

A recommended daily dosage for this type of goal would be 5-10 mg day for 8 weeks.

Recomp muscle growth, lean body mass, muscle gains

SARM Ligandrol LGD-4033 concentration seems to shine with this method due to its anabolic activity and anabolic effects. Many have seen an increase in lean body mass, muscle growth and a decrease in body fat. SARM Ligandrol LGD-4033 seems to work the best with this method.

Ran in conjunction with other SARMS, like CARDA, will only increase the likelihood of a stronger recomp. Recommended doses for recomping would be 5-10 mg a day for 8 weeks.

PCT is recommended after a cycle of SARM Ligandrol LGD-4033 While it may not be quite as suppressive as anabolic steroids, the suppression is much higher than other SARMS, thus, requiring a full PCT.

SARM Ligandrol LGD-4033 is a novel nonsteroidal oral selective androgen receptor modulator for treatment of conditions such as muscle wasting and osteoporosis, discovered by Ligand Pharmaceuticals and under development by Viking Therapeutics.


Ligandrol Side Effects

Two mild side effects associated with SARM Ligandrol LGD-4033 are headaches and dry mouth. However, more troublesome side effects can also occur.

Testosterone Suppression

SARMs, despite being non-steroidal, can still suppress natural testosterone levels, due to aggressive binding to the androgen receptor. This consequently decreases LH (Serum luteinizing hormone levels) and FSH (follicle-stimulating hormone).

SARM Ligandrol LGD-4033 is the most potent SARM on the market, thus it is considered the most suppressive.

Thus, considering users commonly take 5mg/day of LGD 4033 and upwards, testosterone suppression, in this case, is likely to be more severe — indicating significant (yet temporary) damage to the HPTA (hypothalamic-pituitary-testicular axis).

Liver Toxicity

In a randomized clinical trial, SARM Ligandrol LGD-4033 was given to 76 healthy men, producing no notable changes in serum aminotransferases, in dosages of 0.1, 0.3 and 1mg/day, over 21 days (3).

So a liver supplement such as Liver Complex would be recommended whilst taking SARM's such as SARM Ligandrol LGD-4033

Water Retention & Gynecomastia

In theory, SARM Ligandrol LGD-4033 should not produce estrogenic side effects, as it does not aromatize or directly stimulate estrogen receptors.

However, Ligandrol will compete with the body’s natural testosterone for binding to the androgen receptor. SARM Ligandrol LGD-4033 higher affinity means that the body’s natural testosterone loses this battle and instead becomes more available for binding to other receptors — such as estrogen.

Thus, SARM Ligandrol LGD-4033 can indirectly cause higher estrogen levels, increasing the risk of potential bloating or/and gynecomastia. So a PCT is a must after using a cycle of Ligandrol LGD-4033

LGD 4033 Dosage

A dosage has not been established by medical experts at this time, with LGD 4033 yet to be FDA approved. However, in trials, 0.1, 0.3 and 1mg dosages have been commonly used; with higher dosages yielding more pronounced results.

Male weightlifters taking LGD 4033 for physique-enhancing purposes will typically take 2-10mg/day. Females will opt for the lower dosages in this range (2mg/day), to prevent the risk of virilization side effects occurring.

LGD 4033 is administered once per day. Dosages may be tapered, ensuring user’s continue making gains for the duration of their cycle. Thus, 1-2mg/day may be a starting dosage, with increases of 1-2mg each week, until a desired maximum dosage is achieved. Some users may not choose to taper cycles out of convenience.

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