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Viridian Menopause Complex 30 Capsules

  • £24.80

Viridian Menopause Complex

Directions: As a food supplement, take one capsule daily with food, or as directed by your healthcare professional.


One vegan capsule provides:

Ingredient Weight %EC NRV

Lemon balm (Melissa officinalis.L) leaf extract

Standardised to 6% rosmarinic acid 


Hops (Humulus lupus L) flower extract

Standardised to 0.2% 8-prenlnaringenin (8-PN) 


Saffron (Crocus sativus) extract

Standardised to 2% safranal and 3% crocins  

In a base of sage leaf
Plant cellulose capsule


All women experience the menopausal transition, it marks the end of the reproductive period, and it is characterised by a drastic decline of oestrogen to zero production. This means that the menstrual cycle will cease, once the cycle has ceased for 12 months menopause is considered to have occurred. Post menopause a small amount of oestrogen may be produced by the adrenal glands and adipose tissue but in a quantity that is far lower than that produced by women of reproductive age.

The NHS state that the average age of menopause in the UK is 51 years.

However, the perimenopause can start up to 10 years prior whereby menopausal symptoms may start and last up to 8 years post menopause. In approximately one in 100 women a premature menopause may occur, this is menopause prior to the age of 40.


As many as 80% of women experience menopausal symptoms, these include:
  • Changes to menstrual cycle, irregular cycles

  • Cessation of the menstrual cycle

  • Lowered mood and mood swings

  • Anxiety and low self esteem

  • Difficulty with concentration and memory, brain fog

  • Hot flushes

  • Night sweats

  • Chills

  • Insomnia

  • Palpitations

  • Headaches and migraines

  • Muscle and joint aches

  • Change in body shape and weight gain

  • Changes in skin strength, dryness and itching

  • Thinning hair

  • Reduced sex drive

  • Vaginal dryness, pain or itching

  • Recurrent urinary tract infections

  • Fatigue


Research states that over 80% of women will experience menopausal symptoms of varying degrees. Nuffield Health conducted a questionnaire among 3275 women representative of the female UK population. The findings reported that 62% of participants experienced hormonal changes and menopausal symptoms that resulted in a change in behaviour or had a detrimental effect on their lives. Finally, one in four were concerned about their ability to cope due to menopause. 

As suggested, menopausal symptoms have a significant impact on quality of life and HRT is not always appropriate, so, many women are interested in natural options. Consequently, more research interest in the oestrogen buffering effect of Hops has occurred.

Initially the values of 8-PN that were used in pre-clinical studies were investigated in a small randomised controlled trial compared to placebo. A total of 24 healthy postmenopausal women were randomly allocated to receive a single dose of 50, 250 or 750 mg of 8-PN or placebo. The blood markers of 8-PN showed a rapid absorption, with a second peak at around 5 hours. The 750 mg dose demonstrated a decrease in luteinising hormone by 16.7%, elevated levels of luteinising hormone are associated with the cessation of ovulation.

A second randomised, double blind, placebo-controlled study investigated smaller quantities of 8-PN that were administered as a Hops extract. Over 12 weeks, 67 menopausal women were randomly allocated to receive a Hops extract standardised to 100 mcg and 250 mcg 8-PN placebo. The responses were measured using the Kupperman index and a patient’s questionnaire to assess menopausal symptoms. Both the Hops groups showed a significant reduction in the scores after both 6 and 12 weeks which indicated a significant reduction in menopausal symptoms. The 100 mcg Hops extract treatment effect was superior to 250 mcg Hops and placebo.  This suggests efficacy from smaller doses than those used previously.

To further investigate the lower and seemingly more efficacious dose of Hops extract standardised to 100 mcg of 8-PN was investigated for its effect on menopausal discomforts. At 8 weeks of the 16-week randomised, double blind, crossover study improvements in symptomatology were reported for the Hops group, this further improved at 16 weeks in all symptom outcomes.


A major concern in female health is the metabolism of oestrogen into harmful metabolites. The metabolism of oestradiol to oestrone is followed by one of 3 oestrogen metabolites: 2-OHE1, 4-OHE1 or 16α-OHE1. Whereby 16α-OHE1 is considered the most aggressive and harmful.

Subsequently, an in-vitro study investigated the effect of Hops derived 8-PN on oestrogen metabolism in human cells. It was reported that Hops extract preferentially induced the 2-OHE1 pathway in the cells.  Thus, Hops extract has the capacity to offer a protective effect by influencing oestrogen metabolism into less harmful metabolites.


Hops not only provides 8-prenylnaringenin, a potent phytoestrogen but also the prenylflavonoids; xanthohumol and isoxanthohumol (IX). Importantly, IX is transformed in the body to 8-PN, however it is apparent that not all women are efficient 8-PN producers and environmental factors may influence the rate of conversion.

Based on urinary recovery as assessment, 50 healthy, postmenopausal Caucasian women were classified 60% poor, 25% moderate and 15% strong converters of IX to 8-PN. Of interest, antibiotic therapy reduced conversion efficiency. Methane production was positively related to 8-PN production, which may indicate those with a diverse microbiome  and adequate intake of prebiotic fibres are better IX to 8-PN producers. While strong IX to 8-PN producers consumed less alcohol and had a higher theobromine intake a constituent of cacao. This shows that the benefits of Hops can be increased via dietary and lifestyle manipulation.

Saffron Extract


Changes in mood, for the short-, long-term, or as mood swings can be an upsetting menopause symptom. Furthermore, oestrogen is a regulator of the stress hormone, cortisol. Subsequently as oestrogen declines cortisol rises, which increases stress and anxiety levels, leaving a woman questioning her ability to cope.

To offer relief from these disconcerting symptoms a 12-week, parallel group, double blind randomised controlled trial investigated the effect of a saffron extract upon mood and psychological symptoms. A total of 86 perimenopausal women were randomly allocated to receive 14 mg of saffron twice daily or placebo. Saffron was shown to improve mood and psychological symptoms, at 12 weeks a 33% reduction in anxiety and 32% reduction in depression compared to baseline was reported.

Hot flushes are considered a vasomotor symptom of menopause, whereby the temperature control centre of the brain, the hypothalamus becomes dysregulated. Oestrogen and serotonin are highly associated, thus as oestrogen declines so does serotonin and the number of serotonin receptor sites in the brain which results in changes in mood.

Given the impact of menopause depressive symptoms which can affect work, social life and the ability to cope, a random controlled trial investigated the effects of saffron on hot flashes in those with major depressive disorder. Sixty post-menopausal women suffering with hot flashes were randomly allocated to receive 15 mg of saffron extract or placebo given twice daily for 6 weeks. The data analysis demonstrated a significant effect for time x treatment, namely, the improvements increased with duration of saffron use.  Subsequently, the alleviation of hot flushes is a new discovery to add to the catalogue of benefits reported for saffron.

Lemon Balm


Lemon Balm is known for its improvement to mood, a major factor in menopausal symptoms. Subsequently, a group of researchers investigated the effect of lemon balm on menopausal symptoms using the Menopause Rating Scale (MRS). Sixty postmenopausal women were recruited and randomly allocated to receive 250 mg of Lemon Balm or placebo taken twice daily. By the 4-week mark the Lemon Balm group had a significantly lower MRS score than the placebo group, which perpetuated to 8 weeks. 


Issues with sleep is commonly reported by women during the menopause. The regulation of the stress and wakefulness hormone, cortisol is regulated by oestrogen. Subsequently when oestrogen levels decline as characterised in menopause, cortisol levels creep up to the extent that sleep is interrupted by cortisol’s inhibition of melatonin, the sleep hormone.

Subsequently, a triple blind randomised controlled trial that recruited 100 menopausal women aged 50-60 years who were suffering with insomnia investigated the effect of Lemon Balm on insomnia. The participants were randomly allocated to receive either 250 mg of Lemon Balm or placebo, twice daily for one month. A total of 20% of the Lemon Balm group showed sleep improvements. Additionally, the average sleep score was significantly higher in the Lemon Balm group when compared to placebo which indicated improved sleep. 

To evaluate the standard of efficacy, Lemon Balm was compared to citalopram, a commonly prescribed SSRI, to investigate the quality of life in menopausal women with a sleep disorder. Sixty postmenopausal women with a sleep disturbance diagnosis were recruited to randomly receive 500 mg of Lemon Balm, 30 mg of citalopram or placebo daily for 8 weeks. Menopause specific quality of life scores were significantly improved in the Lemon Balm group compared to citalopram and placebo. Significant improvements were shown in vasomotor, psychomotor-social, physical and in the sexual domain symptoms. 



Revered in traditional medicine Sage is rich in phytoestrogens and along with its antibiotic, anti-anxiety, anti- fungal, hypoglycaemic effects, it has been historically used to manage the symptoms of menopause. To gain research evidence Sage was investigated its effect on the full range of menopausal symptoms, 30 postmenopausal women were recruited, they experienced varying degrees of hot flushes. The women were given 100 mg of Sage for 4 weeks. The results showed a decrease in the severity of hot flashes, night sweats, panic, fatigue and concentration by the end of the study. 


Hot flushes are a sudden feeling of warmth in the upper body which becomes intense in the face, neck and chest and triggers sweat and a flushing of the skin. Women are often very sensitive to the effects of this symptom. It may contribute to self-consciousness, for example, that their clothes may have sweat marks, that they smell sweaty, or their makeup has run. In Switzerland, 71 patients who had been menopausal for at least 12 months and experiencing hot flushes were recruited to use Sage each day for 8 weeks.

There was a significant decrease in the total score of the mean number of intensity-rated hot flushes by 50% in the first 4 weeks and by 64% within 8 weeks. The mean total number of hot flushes per day decreased significantly each week from week 1 to 8. The mean number of mild, moderate, severe, and very severe flushes decreased by 46%, 62%, 79% and 100% over 8 weeks, respectively. 

Both the Sage studies would be improved if repeated and compared the intervention to placebo; however, the positive findings support anecdotal evidence and traditional use.



Reduction in intensity of hot flushes Moderate Severe Very Severe




Hops Extract (standardized to 8-PN)


Saffron Extract


Lemon Balm


In a base of sage


Plant cellulose capsule


Taken as a food supplement the directions for adults are one capsule daily with food. Recommended use:

Not recommended for the use of children, during pregnancy or lactation.

Pregnancy and breast-feeding

Not to be used during pregnancy and lactation.