Why is RAD 140 one of the most popular Selective Androgen Receptor Modulators?

War Torn Labz RAD 140 Selective Androgen Receptor Modulators oral administration is used as a dietary supplement

RAD140 is a supplement with anabolic effects which allows people to achieve their fitness and weight loss objectives which are hindered by fat loss plateau and strength limitations. Also known as Testolone, RAD140 is a supplement that is consumed orally. RAD140 has the same effect as Testosterone and has a high anabolic activity with a high Anabolic Androgen Action.

It can stimulate the muscle and bone of the body while still manage to suppress the prostate tissues and seminal vesicle. This means it doesn’t increase sperm production contrary to popular belief. Here are some of the benefits of RAD140.

LEAN GROWTH IMPROVED SIZE LIFT MORE VEGGIE CAPSULES, HALAL CERTIFIED USA MADE How Does Testolone Work

 

How does RAD140 testolone work?

It works in a very similar way to the way steroids work. The difference is that Testolone selectively targets the androgen receptors to bind to. Steroids, on the other hand, don’t selectively target and because of that, they cause a lot more side effects.

So RAD140 selectively targets androgen receptors to bind to. More specifically, it targets the androgen receptors in our muscle tissue and skeleton. Because of that, it has great benefits of increased muscle mass and fat loss (we will go over the benefits later).

Does RAD 140 Increase Strength?

 

This benefit is what RAD140 is infamous for. The strength gains are absolutely incredible, probably one of the best among all SARMs.

In my experience and according to other people, RAD140 is one of the best SARMs for gaining a lot of strength. This is also why a lot of competitive CrossFitters are using this compound.

 

You will feel stronger almost instantly and all of your lifts will increase week after week. Testolone is amazing for breaking strength plateaus.

 

Most people gain 25lbs on all of their major lifts (bench press, squat, deadlift).

 

 

The best thing about this is that you will be able to keep most of your RAD140 strength gains after the cycle is over if you train hard. Obviously, if you quit training after the cycle, your strength will go down.

Dose Levels for RAD140.

RAD140 Dosage And Cycle Length

I recommend a dosage between 5mg to 30mg per day for an 8-week cycle. Clinical studies have shown, that a 5mg dose is 80-90% as effective as the 30mg dose is. This means that if you take 10mg a day you will see great results and have literally no side effects, assuming you have real RAD140.

In our in-depth RAD 140 dosage guide we go over the best and safest cutting and bulking Testolone dosages as well as the dosages used in human trials. If you’re interested in that, please go check it out.

I also recommend that you don’t cycle over 10-weeks, this is just so you can get away with not using a PCT. If you use 5mg for 8-weeks you definitely won’t need one.

what is RAD140 Half-Life?

From numerous research results, we know that the half-life of Testolone is 24 hours.

This means that we should take a dosage of RAD140 once every 24 hours to keep the levels of the compound in our body optimal. If we do this, we will make sure that Testolone will work at full capacity throughout the cycle and this means great results.

Is a PCT required after a course of RAD140 testalone?

Yes we would recommend a Actions relevant 4 week Post Cycle Therapy course immediately after running a course of RAD140 as due to testosterone suppression there is a possibility of a decline in testosterone levels.To avoid aromatization to estrogen 

 

Unlike test however there doesnt seem to be any negative action in prostate health or drug induced liver injury and appears to have an acceptable safety profile. Due to there being no drug-induced liver injury liver supplements such as milk thistle are not required.

Other Side Effects

Testosterone suppression can be dependant on dosage and length of cycle.

 

Some people experience weird side effects from their RAD140 such as hair loss, headaches, stomach aches, etc.

This is very weird because RAD140 is well researched and we have a lot of data from human trials and studies available.

So the reason why some people get weird side effects is that their Testolone is bunk.

Sadly, a lot of companies sell bunk RAD140 and other SARMs that have other substances mixed into the product. These substances can cause a lot of weird side effects and make the product a lot less safe. This is why it’s so important that you buy high-quality, pure RAD140.

Buy quality - not all products are the same.

Selective Androgen Receptor Modulator ARE FOR RESEARCH PURPOSES ONLY. THIS PRODUCT IS NOT A NUTRITIONAL SUPPLEMENT, NOR A FOOD AND SHOULD NOT BE USED AS ONE. THIS PRODUCT IS SOLELY FOR RESEARCH PURPOSES ONLY.

 

 

Technical stuff and research

Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models with a Distinct Mechanism of Action

RAD140 exhibited potent antitumor activity in the in vivo models of AR/ER+ breast cancer both as a single agent and in combination with the CDK4/6 inhibitor palbociclib.

To further assess how the AR agonist activity of RAD140 translates into antitumor activity in vivo, RAD140 was evaluated as a single agent in AR/ER+ breast cancer PDX models.

In the HBCx-22 model, fulvestrant, a selective ER downregulator (SERD) and standard of care for ER+ breast cancer dosed at 1 mg weekly, exhibited a statistically significant antitumor activity, as judged by a TGI of 59%, comparable with a previous report of this model and indicative of its dependency on ER.

 

RAD-140 (SARMs) Testolone Review

Loss of body fat and increases in strength – RAD-140 is not a substance typically used for losi, but due to strong anabolic activity and accelerated metabolism, it helps to lose several percentages of body fat.

Although ER-positive (ER+) breast cancers are now treated with standard-of-care agents targeting the ER axis, including tamoxifen, fulvestrant, and aromatase inhibitors (AI), and HER2-positive tumors are treated with HER2 inhibitors, such as trastuzumab, novel therapeutic approaches are still needed to address resistance emerging from these established regimens.

 

Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models with a Distinct Mechanism of Action

Although ER-positive (ER+) breast cancers are now treated with standard-of-care agents targeting the ER axis, including tamoxifen, fulvestrant, and aromatase inhibitors (AI), and HER2-positive tumors are treated with HER2 inhibitors, such as trastuzumab, novel therapeutic approaches are still needed to address resistance emerging from these established regimens.

 

Some people experience weird side effects from their RAD140 such as hair loss, headaches, stomach aches, etc.

 

It can stimulate the muscle and bone of the body while still manage to suppress the prostate tissues and seminal vesicle. This means it doesn’t increase sperm production contrary to popular belief. Here are some of the benefits of RAD140.

In this study, we investigate the SARM RAD140 in cultured rat neurons and male rat brain for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases.

In transgenic mouse models of AD, depletion of endogenous androgens by surgical or chemical castration accelerates development of AD-like pathology whereas elevation of endogenous testosterone above normal levels significantly impedes pathology development.

RAD140 protects cultured neurons against Aβ in a dose-dependent manner As an initial step to evaluate the neuroprotective potential of RAD140, we compared RAD140 with the endogenous androgens T and DHT for their relative abilities to reduce neuron death induced by aggregated Aβ1–42, the peptide implicated in AD neurodegeneration.

Because SARMs can interact with AR differently than endogenous androgens, the efficacy of specific SARMs in activating defined androgenic pathways is a key consideration in pursuing translational muscle gain goals.

However, the clinical utility of the classic steroidal androgen-based therapies has been limited.

 

A commentary has been published: Split-Screen Abstract Purpose: Steroidal androgens suppress androgen receptor and estrogen receptor positive (AR/ER+) breast cancer cells and were used to treat breast cancer, eliciting favorable response.

However, the clinical utility of the classic steroidal androgen-based therapies has been limited.

Clinically, until the 1970s, breast cancers were often treated with nonselective steroidal androgens including testosterone derivatives and danazol with response rates of 20% to 25%.

 

The result is the rapid growth of lean muscle mass (while promoting the burning of excess body fat), as well as effective strengthening of bones by increasing their density.

In any case, the action is not only about strengthening the muscles and the faster reconstruction of a hard lean muscle mass.

Testolone

Compared to anabolic agents, SARMs have reduced androgenic properties.

To overcome this limitation, novel compounds termed “selective androgen receptor modulators” (SARMs) have been developed that lack significant androgen action in prostate but exert agonist effects in select androgen-responsive tissues.

The loss of androgens with normal aging can negatively impact androgen-responsive tissues, including the brain, and has been shown to be a significant risk factor for development of neurodegenerative disorders including AD making RAD 140 potentially a neuroprotective agent.

Testol 140 is a dietary supplement that forms lean muscles by following simple and clear-cut methods.

The powerful ingredients work in conjunction to develop lean muscles, increase metabolism, speed up muscle regeneration, and promote fat burning.

Nevertheless, let's see more “practically” this two-way action of RAD 140 - On muscle tissues RAD 140 (or Testolone) provides a huge energy boost for the body, but also a muscular strengthening, favoring training whilst causing enhancement of muscle mass as well as maximising muscle gain goals.

SARMs are ligands for AR that exert limited effects in prostate and other reproductive tissues but have potent androgenic actions in muscle and bone.

RAD-140 is more anabolic than testosterone and has a 90:1 ratio of anabolic to androgenic action making RAD-140 one of the most sought after SARM'S on the market with incredible recovery times, whilst causing enhancement of muscle mass as well as maximising muscle gain goals.

RAD140 exhibited potent antitumor activity in the in vivo models of AR/ER+ breast cancer both as a single agent and in combination with the CDK4/6 inhibitor palbociclib.

RAD-140 is classed as a S.A.R.M, a class of compounds developed to increase muscle tissue without the side effects seen with anabolic steroids and has rapidly won favour among users for its extremely potent physiologicial effects.Users of RAD-140 report much improved recovery times, a rapid enhancement of muscle mass, faster strength gains and improved endurance.In order to maintain gains after a SARMs cycle and feel mentally and physically well by kickstarting endogenous testosterone production and preventing any unwanted excessive oestrogen conversion, PCT is a must.

Rad140 and protein synthesis

It is also necessary for protein synthesis in order to restore tissue and reduce inflammation.

Testosterone promotes protein synthesis, increases muscle mass, and generates a host of health benefits.

With 90:1 ratio of anabolic to androgenic effects it makes RAD-140 exceptionally well suited for enhancing body composition both by increasing muscle mass and lowering fat while also avoiding androgenic sides such as hair loss and acne. So very few side effects whilst causing enhancement of muscle mass as well as maximising muscle gain goals.