What are the effects of Quercetin and Vitamin B5 Complex?

What does Quercetin do?

The effects of Quercetin and vitamin B5 with nettle extract, chamomile flower, pine bark extract, bromelain (from pineapple) and acerola fruit, plus vitamin C. Vitamin B5 (pantothenic acid) contributes to normal mental performance and a reduction in tiredness and fatigue. Vitamin B5 also contributes to the normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters. These dietary Flavonoids and dietary antioxidants have quite extraordinary biological effects.

QUERCETIN is one of several bioflavonoids (special nutrients found with vitamin C in fruit and vegetables) with anti-inflammatory, anti-oxidant and anti-histamine properties. Quercetin consistently demonstrates the greatest activity among the flavonoids studied, with many medicinal plants owing much of their activity to their high quercetin content. In addition, bioflavonoids strengthen capillary walls, which help prevent spider veins, varicose veins, and hemorrhages and bruises. They also work as an anti-inflammatory agent by deactivating enzymes that produce inflammation.

• ANTI-INFLAMMATORY effects of quercetin 

• Action of Quercetin -Quercetin demonstrates significant anti-inflammatory activity via several actions including inhibition of mast cell and basophil degranulation, neutrophil and monocyte lysosomal secretion, prostaglandin formation (particularly leukotrienes), and lipid peroxidation. A membrane stabilising effect is known to be part of the anti-inflammatory effect. Quercetin has also been shown to inhibit the enzyme hyaluronidase (responsible for the breakdown of collagen matrix of connective tissue). Leukotrienes promote inflammation by causing vaso-constriction, which can then lead to vascular permeability and bronchoconstriction.

• ANTI-ARTHRITIC (OSTEO – AND RHEUMATOID)

• In addition to reducing leukotrienes, quercetin is also beneficial due to its antioxidant properties helping to stabilise collagen, the material needed by the body to maintain healthy joint tissue.

• ANTI-ALLERGIC

• Quercetin inhibits the manufacture and release of histamine and other allergic /inflammatory mediators. The release of histamine and other inflammatory mediators from mast cells and basophils is involved in the cause of acute allergic and inflammatory responses. Mast cells are found in the highest concentrations in the body, in the blood vessels of the respiratory tract, conjunctiva, gastrointestinal tract, and the skin.

• ANTIOXIDANT Properties 

• Clinical trials have demonstrated that quercetin prevents the production of free radicals.

• ANTI-VIRAL

• Studies have shown that quercetin is further thought to decrease the infectiousness of certain RNA and DNA viruses, such as herpes, polio, and Epstein-Barr, by inhibiting their replication. Quercetin is likely to be of benefit in fighting the common cold.

• GLYCEMIC DISORDERS

• one of the beneficial effects Quercetin has been shown to inhibit the enzyme aldose reductase. This enzyme appears to contribute to worsening of retinopathy. However, because the absorption of quercetin is limited, it is questionable whether supplementing with quercetin can produce the tissue levels that are needed to inhibit aldose reductase. Although human studies have not been done using quercetin to treat retinopathy, some doctors prescribe 400 mg of quercetin three times per day.

  In addition to its effect on aldose reductase, quercetin is also of value for its ability to enhance insulin secretion and protect the pancreatic beta-cells from the damaging effects of free radicals, and for its inhibition of platelet aggregation.

Other benefits of Quercetin has been shown to inhibit the enzyme aldose reductase. This enzyme appears to contribute to worsening of retinopathy. However, because the absorption of quercetin is limited, it is questionable whether supplementing with quercetin can produce the tissue levels that are needed to inhibit aldose reductase. Although human studies have not been done using quercetin to treat retinopathy, some doctors prescribe 400 mg of quercetin three times per day.

In addition to its effect on aldose reductase, quercetin is also of value for its ability to enhance insulin secretion and protect the pancreatic beta-cells from the damaging effects of free radicals, and for its inhibition of platelet aggregation.

What does VITAMIN B5 do?

• (pantothenic acid) is found in varying amounts in virtually every food, hence its name derived from the Greek pantos, meaning everywhere. It is a water-soluble vitamin that has a key role in the release of energy from foods. It is also needed for healthy growth and the production of antibodies to help fight infection.

• ENERGY

• This key B vitamin helps to convert food into energy and is essential for the normal functioning of the adrenal glands, along with other benefits.

• ANTI-STRESS

• Vitamin B5 is the main nutrient for nourishing the adrenal glands. It is needed by the adrenal glands to make glucocorticoids, which may be the reason that B5 is known as the anti-stress vitamin.

• MEMORY

• It is vital for making the neurotransmitter acetylcholine and is thought to boost memory.

• ARTHRITIS

• It has also been found to be helpful in arthritis. The adrenal glands are involved in the release of cortisone, the body’s natural anti-inflammatory hormone. In this way, if the body requires cortisone (ie: in arthritis or allergic conditions), a well-nourished body that has all the necessary vitamin B5, will help to produce all the natural cortisone required. Supplements of vitamin B5 have been found to reduce pain and stiffness in cases of rheumatoid arthritis. Deficiency symptoms include poor muscle co-ordination, muscle cramps, numbness and tingling, painful burning feet, depression, fatigue, weakness, headache and loss of appetite.

  What does BROMELAIN do?

Potential benefits - It has also been found to be helpful in arthritis. The adrenal glands are involved in the release of cortisone, the body’s natural anti-inflammatory hormone. In this way, if the body requires cortisone (ie: in arthritis or allergic conditions), a well-nourished body that has all the necessary vitamin B5, will help to produce all the natural cortisone required. Supplements of vitamin B5 have been found to reduce pain and stiffness in cases of rheumatoid arthritis. Deficiency symptoms include poor muscle co-ordination, muscle cramps, numbness and tingling, painful burning feet, depression, fatigue, weakness, headache and loss of appetite.

• is an enzyme found in the stem of the pineapple plant as food sources that helps digest food and absorb nutrients.

• DIGESTION

• Bromelain is helpful for general protein digestion. Bromelain has been shown to be a good substitute for trypsin or pepsin in cases of pancreatic insufficiency.

• ANTI-INFLAMMATORY

• Bromelain reduces inflammation by stimulating the production of plasmin, which breaks down fibrin, a tough protein structure that walls off the area of inflammation. Plasmin also blocks the production of pro-inflammatory compounds. Bromelain has also been shown to inhibit the production of kinins, inflammatory chemicals that are involved in causing swelling, inflammation and pain. Bromelain offers good support in aiding healing of sports injuries such as bruising and chronic inflammation

• ANTIBIOTIC

• Research has shown bromelain to be as effective as anti-biotics in treating a variety of infectious processes e.g. pneumonia, perirectal abscess, cutaneous staphylococcus infection, pyelonephritis, and bronchitis.

• CELLULAR PROTECTION

• Bromelain has demonstrated good effects in research, and it is believed to work by breaking down the cell’s fibrin coat, providing the immune system with more ready access to them.

Bromelain has demonstrated good effects in research, and it is believed to work by breaking down the cell’s fibrin coat, providing the immune system with more ready access to them.

What does CHAMOMILE do?

• is a daisy like plant of the Asteraceae family and has been used for thousands of years, dating back to the ancient Egyptians, Romans, and Greeks.

• ANTI-INFLAMMATORY

• In human studies, anti-inflammatory, antiseptic, antispasmodic effects have been attributed to compounds known as flavonoids and sesquiterpenes. These anti-inflammatory compounds may aid in healing infections and reducing puffiness under the eyes experienced with hay fever.

• ANTI-HISTAMINE

• Contains natural antihistamines that can fight against histamines in the bloodstream. Antihistamines can treat allergies, colds, and sinus problems by blocking histamines and alleviating symptoms caused by excess histamines in the blood. Chamomile has shown to help relieve the symptoms of hay fever without causing drowsiness in contrast to some over the counter medications.

• DIGESTION

• Chamomile has been used traditionally to treat stomach cramps, irritable bowel syndrome, indigestion, diarrhoea, gas, and colic. It helps relax muscle contractions, particularly in the smooth muscles found in the intestines.

  VITAMIN C is a cofactor for many enzyme systems and is involved in the synthesis of collagen, carnitine, endocrine hormones, and neurotransmitters.

Chamomile has been used traditionally to treat stomach cramps, irritable bowel syndrome, indigestion, diarrhoea, gas, and colic. It helps relax muscle contractions, particularly in the smooth muscles found in the intestines.

VITAMIN C is a cofactor for many enzyme systems and is involved in the synthesis of collagen, carnitine, endocrine hormones, and neurotransmitters.

• IMMUNE FUNCTION

vitamin C is known to be a potent immune stimulating nutrient. It has been shown to inhibit viral replication and may reduce the severity of the common cold.

Clinical assessment has demonstrated that 2000mg of vitamin C per day for two weeks reduced blood histamine concentrations by 30-40% in adult subjects, offering benefit from conditions such as allergic rhinitis.

• ANTI-HISTAMINE

• Vitamin C is a natural antihistamine. It both prevents histamine release and increases the detoxification of histamine. A study found that taking 2 grams of vitamin C daily lowered blood histamine levels 38 percent in healthy adults in just one week. It has also been noted that low concentrations of serum vitamin C have been correlated with increased serum histamine levels.

• High ANTIOXIDANT Activity

• vitamin C performs many functions including acting as an antioxidant and protecting cellular structures, including DNA from damage.

  What does NETTLE do?

• is a herbaceous perennial flowering plant, native to Europe, Asia, northern Africa, and North America, and is the best-known member of the nettle genus Urtica.

• ANTI-HISTAMINE

• contains biologically active compounds that reduce inflammation. Nettle leaf reduces the amount of histamine produced by the body in response to an allergen. Nettle works differently to conventional antihistamines which block the histamine receptor only masking the symptoms of an allergic response. This process can sometimes backfire as the immune system overacts even further to the perceived threat.

• ANTI-INFLAMMATORY

• nettle can interfere with the body's production of prostaglandins and other inflammation-causing chemicals. Consequently, nettle may have an anti-inflammatory effect. It may also enhance responses of the immune system.

• ANALGESIC

• Chemicals in nettle's aerial parts are also thought to reduce the feeling of pain or interfere with the way that nerves send pain signals. All these effects may reduce the pain and stiffness of arthritis and other similar conditions.

  What does PINE BARK EXTRACT do?

Chemicals in nettle's aerial parts are also thought to reduce the feeling of pain or interfere with the way that nerves send pain signals. All these effects may reduce the pain and stiffness of arthritis and other similar conditions.

• is a rich source of the plant flavonoids proanthocyanidins (OPCs). The OPCs are the pigment materials which give flavour, colour and aroma to many plants and fruits.

• ANTI-HISTAMINE

• Bioflavonoids present in pine bark extract have been shown to block histamine release. Professor Sharma from the University of Dublin has shown that it inhibits histamine release from mast cells. This is due to the free-radical scavenging property of pine bark extract.

• ANTIOXIDANT ACTIVITY

• OPCs protect against free-radical damage, suggested to be a major cause of the ageing process. The antioxidant effect is 50 times greater than that of vitamin C and E. A major advantage of these molecules is that they are taken up into the cell membranes and protect against both water- and fat soluble free-radicals.

  What does ACEROLA do?

• The fruit of the Acerola Cherry tree, Malpighia punicifolia L. is rich in Vitamin C and carotenoids, with the cherry-like fruits being one of the richest known natural sources of vitamin C.

• ANTIOXIDANT

• acerola's use is mostly associated with its high content of vitamin C and the synergistic bioflavonoids- rutin and hesperidin, providing one of nature’s most potent antioxidants.

• IMMUNE SUPPORT

• acerola is an ideal food-based source of nutrients necessary for immune support. Acerola is a rich source of vitamin C, bioflavonoids, carotenoids, and other vitamins, minerals and phytonutrients providing ideal synergy for immune cell function.

NUTRITIVE

Compared to oranges, acerola provides twice as much magnesium, pantothenic acid, and potassium. Other vitamins present include vitamin A (4,300 to 12,500 IU/100 g, compared to approximately 11,000 IU for raw carrots), thiamine, riboflavin, and niacin in concentrations comparable to those in other fruits. Acerola cherries are an excellent source of powerful antioxidant activity and positive antioxidant effects and are also rich in protein and mineral salts principally, iron, calcium and phosphorus.

Dosage

100-300 mg quercetin daily 20 mins before meals. Two capsules daily.

Adverse effects - none

What are the potential health benefits of Quercetin Supplementation?

Quercetin appears to be indicated in virtually all inflammatory Diseases and allergic conditions, including hayfever, arthritis, lupus, food allergies, eczema and psoriasis.

Dietary Intake: Doses of Quercetin. As a food supplement, take two capsules daily with food, or as directed by your healthcare practitioner.

two vegetarian capsule provide:

Urtica dioica) extract (4:1) Matricaria recutita) Malphigia glabra)