Viridian Synbio Daily Plus Cranberry 30 Capsules
Synerbio Daily with Cranberry Veg Caps is an expert formulation comprising good gut bacteria (commonly known as probiotics) with added ‘prebiotics’.
The unique Prebiotic FS2-60 offers full-spectrum prebiotic oligosaccharide and plant-derived inulin. FS2-60 is not digested but is utilised by the friendly flora to increase colonisation of Lactobacilli and the Bifidobacteria whilst reducing the foothold of unfriendly species. The daily blend of multi-strain good bacteria provides cranberry extract which is the equivalent to 300ml of cranberry juice and Vitamin C, which contributes to the normal function of the immune system.
The human gut is home to an immense population of bacteria. Some 100 trillion bacteria populate the human gut, a number that is 10 times greater than the number of cells in the human body. Because of the sheer size and importance of the gut bacteria, this microbial population can be viewed as a bacterial organ, about the size of your liver and just as important.
Take one capsule daily with food or as recommended by a healthcare practitioner.
One capsule provides
CystiCranTM Cranberry extract
(providing 36mg proanthocyanidins)
|Vitamin C (as magnesium ascorbate)||100mg||125|
|Total viable good bacteria count:||3 Billion CFU|
Lactobacillus acidophilus DDS-1
Bifidobacterium breve PBS 077
Bifidobacterium infantis B1 072
Bifidobacterium longum BLG 240
(Guaranteed at time of manufacture)
*Full spectrum prebiotic fructooligosaccharide and plant-derived inulin
|Vitamin C contributes to the normal function of the immune system.|
There are some 400 species of bacteria in the gut including Bacteroides, Lactobacillus, Clostridium, Fusobacterium, Bifidobacterium, Eubacterium, and Peptostreptococcus. Gut bacteria with identified as suitable ingredients in food supplements include Bifidobacterium and Lactobacillus species.
Urinary tract infections (UTIs), also known as cystitis, occur when a bacteria, normally E.coli, infects the urinary system and can affect the bladder, urethers and/or kidney. UTIs are far more common in women than men, and it is estimated that one in five women will have a UTI at some point in their life with high recurrence rates of up to 20%.1 Recurrence after an infection is high, with 53% of women above the age of 55 years and 36% of younger women reporting a recurrence within 1 year.2 UTIs are normally treated by GPs with antibiotics, however this does not prevent the return of an infection in those who are prone to recurrence.
Recurring UTIs are sometimes associated with bacteria from the bowel infecting the urethra, which explains why women are anatomically more prone to infection. Women’s urethras are also shorter than men’s making it easier for bacteria to travel up to the bladder. Symptoms of UTIs include an intense urge to urinate with a burning sensation on urination. Urine can be cloudy and have a foul smell.
This berry has a long history of use for UTIs and is believed to provide its benefits through a number of different mechanisms. Some research suggests that cranberry is capable of reducing the ability of the bacteria to adhere to the urinary tract cells3, 4 Other evidence has highlighted that cranberry is able to reduce urine pH via increased hippuric acid excretion which aids in bacterial infection as it creates an unfavourable environment.5,6
Cranberry is effective for preventing recurring UTIs. A systemic review looking at 4 randomised controlled trials (RCTs) concluded that there was strong evidence that cranberry supplementation can reduce UTIs particularly in women susceptible to recurrent UTIs.
Cranberry prevents UTI’s
Cranberry is also effective in older age. A study looking at elderly subjects found that supplementation of cranberry extract twice daily for 12 months significantly reduced clinically defined UTIs.8 A RCT found that cranberry juice significantly reduces the frequency of UTIs in elderly women. Another study looking at both cranberry juice and cranberry extract in women concluded that both lead to a reduction in the number of participants experiencing a UTI within a year compared to placebo.
It is the Proanthocyanidin (PAC) content which appears important in regards to the beneficial activity of the cranberry for UTIs. In a clinical study evaluating the dosage effect of cranberry powder found that to achieve a bacterial anti-adhesion effect in urine, 36 mg of cranberry PAC equivalents per day was effective.11 In addition, a systematic review of the evidence stated that cranberry products should provide at least 36 mg daily to ensure that they provide enough of this active ingredient to be effective.
PROBIOTICS - Probiotics are defined as non-pathogenic microorganisms that, when ingested, exert a positive influence on the health or physiology of the host. In other words, they are good bacteria with positive health effects. Probiotics usually consist of yeast or bacteria (especially Bifidobacterium and Lactobacillus species) and are widely available as nutritional supplements.13
One of the best and longest studied probiotic bacteria is the unique Lactobacillus acidophilus DDS-1 strain. In the early 1960s when very few people were interested in probiotics, Professor Khem Shahani began to study probiotic bacteria, and eventually his group isolated and then began a detailed investigation on the properties of a strain of Lactobacillus acidophilus, which he called the DDS-1 strain. This strain survived stomach acidity, was resistant to bile salts, and could grow well in an intestinal environment.15 It is the genus ‘lactobacillus’ which is thought to dominate the urogential flora in women, therefore it is believed that restoring the environment with lactobacillus may protect against UTIs
A number of early human clinical studies were able to demonstrate the ability of Lactobacillus acidophilus DDS-1 to improve gut bacterial health with daily supplementation. In one such study, daily supplementation with just 2 million viable Lactobacillus acidophilus DDS-1 decreased faecal coliform bacteria (e.g. E. coli, Enterobacter, Klebsiella) and increased lactobacillus counts. Faecal beta-glucuronidase and beta-glucosidase activities decreased when acidophilus enhanced milk was ingested.
There are papers outlining the potential link between probiotic use and the prevention of UTIs17 A review of recent literature has outlined that there is good evidence to suggest that probiotic supplementation can be beneficial in preventing recurring UTIs in women.18 A met-analysis of the current literature also concluded that lactobacillus supplementation was both safe and effective in treating women with UTIs.19
PREBIOTIC FS2-60TM - Prebiotic FS2-60TM is a full-spectrum prebiotic comprised of oligosaccharides and plant-derived inulin and works synergistically with probiotics.
Prebiotics are natural fibers that improve the balance of good gut bacteria and the effect of probiotics by providing substrate for their growth. A full-spectrum prebiotic provides a mixture of both short-chain (e.g. oligosaccharide) and longer-chain prebiotics (e.g. inulin). Short and longer chain prebiotics act at different sites in the large intestine (colon) so a full-spectrum blend will nourish bacteria throughout the colon. Full-spectrum prebiotics provide the full range of molecular link-lengths from 2 to 60 links per molecule and are amongst the best-studied types of prebiotics.20
A probiotic supplement that features well-studied strains of bacteria and also includes prebiotics is called a “Synbiotic.” Synbiotics may be superior to probiotics or prebiotics alone as they can improve the survival and establishment of probiotic supplements in the gastrointestinal tract. In addition a synbiotic can selectively stimulate the growth of several species of native good bacteria, thus improving gastrointestinal and overall health.21
Dosage : One capsule daily with food or as recommended by a healthcare professional. Potential applications: Prevention of recurring urinary tract infections and interstitial cystitis.
Safety: No known safety issues. Safe to take during pregnancy and lactation.
Known contraindications: Professional supervision is recommended for people taking immunosuppressant
medications or who are immune-compromised e.g. infants, elderly or critical illness.
Interactions: Patients taking Warfarin should use cranberry supplementation with caution and check with their healthcare professional as there is a potential interaction22. An interaction has also been noted between cranberry and proton pump inhibitors therefore it is advisable to take this supplement away from this medication.23
Useful Links: Cranberry Mannose pH, Essential Female Multi.